All deployed proxies will be on the MP cache at the point of load itself. This means that more the deployed proxies, more the effect on the runtime memory. So this needs to be used judiciously because large proxies can take up unnecessary process memory. There is no specific guideline, but this should be tuned keeping in mind the effect on the JVM memory. Also high number of proxies will increase MP bootup time.
At deployment time the base path of bundle is validated across all the deployed bundles. This means the time taken is directly proportional to the number of deployed bundles. Hence this is a tuning exercise keeping in mind memory and load times.
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